| EX1887 STEROID PANEL: 21- HYDROXYLASE DEFICIENCY |
| Specimen: |
2 mL (1 mL min.) serum from 1 Red Top (No Additive) tube. Do not use SST gel barrier tubes. Ship refrigerated or frozen. Diurnal variation present; take sample between 8-10 am OR 4-6 pm. Specify time and date on specimen container and test request form. |
| Stability: |
| Room |
Refrigerated |
Frozen |
| 8 hrs |
7 days |
7 weeks |
|
| Method: |
LC-MS / MS |
| Comment: |
LC-MS/MS is the gold standard for steroid hormone assays due to increased sensitivity & specificity as compared to immunoassays. Endocrine Society Clinical Practice Guidelines (2018) recommend second-tier screening for CAH by LCMS/MS. |
| Report: |
Contact us to know the TAT. |
| Usage: |
Steroid 21- hydroxylase deficiency accounts for more than 90% of the cases of Congenital Adrenal Hyperplasia (CAH). The classical form of CAH presents in childhood with markedly raised 17- hydroxyprogesterone (17-OHP). Neonates are screened for CAH by testing 17-OHP levels to reduce mortality and other serious sequelae. False-positive results can occur due to physiological stress. Steroid profiling by LCMS/MS improves the positive predictive value of newborn screening for Congenital Adrenal Hyperplasia (CAH). |
| Doctor Specialty: |
Endocrinologist |
| Disease: |
Disorders of Adrenal Gland |
| Components: |
*17 Hydroxyprogesterone *Androstenedione *Cortisol *21-deoxycortisol *17-Hydroxyprogesterone + 21 deoxycortisol : Cortisol Ratio |
| Courier Charges: |
0.00 |
| Home Collection: |
Available (*T&C Apply) |
| Department: |
GENETICS |
| Pre Test Information: |
Diurnal variation present; sample will be taken between 8-10 am OR 4-6 pm. |
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