| EX1180 IMMUNOHISTOCHEMISTRY: GLUTAMINE SYNTHETASE |
| Specimen: |
Submit Tissue in 10% formal-saline OR formalin-fixed paraffin-embedded Tissue Block. Ship at room temperature. |
| Stability: |
| Room |
Refrigerated |
Frozen |
| NA |
NA |
NA |
|
| Method: |
IHC |
| Comment: |
Samples received on holidays will be reported in the next schedule / next working day. |
| Report: |
Contact us to know the TAT. |
| Usage: |
Glutamine synthetase (GS) is an enzyme that catalyzes the ATP-dependent condensation of glutamate with ammonia to form glutamine. GS can be used with a panel of IHC markers like Beta-catenin, Liver fatty acid-binding protein, C-reactive protein, and Amyloid-A to distinguish Hepatic adenoma from Focal nodular hyperplasia and nonneoplastic liver. GS, a target gene of Beta-catenin, is expressed in Hepatic adenomas with Beta-catenin mutations (type 2) but is not expressed in Hepatic adenomas without Beta-catenin mutations. GS is expressed in zone 3 of the normal liver and has a characteristic map-like pattern in Focal nodular hyperplasia. It is mainly used for the classification of Hepatic adenomas and the identification of Focal nodular hyperplasia. |
| Doctor Specialty: |
Oncologist |
| Disease: |
Cancer |
| Components: |
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| Courier Charges: |
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| Home Collection: |
Available (*T&C Apply) |
| Department: |
Histopathology |
| Pre Test Information: |
Provide a copy of the Histopathology report, Site of biopsy, and Clinical history. |
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