| EX0665 FISH: AGGRESSIVE LYMPHOMA PANEL |
| Specimen: |
Submit formalin-fixed paraffin-embedded Tissue Block. Ship at room temperature. Tissue block must contain at least 10% tumor tissue OR 4 mL (3 mL min.) Whole blood OR 4 mL (2 mL min.) Bone Marrow from 1 Green Top (Sodium Heparin) tube. Ship at 18-22°C. DO NOT FREEZE. |
| Stability: |
| Room |
Refrigerated |
Frozen |
| Ship at specified temperatures within 48 hrs |
Ship at specified temperatures within 48 hrs |
Ship at specified temperatures within 48 hrs |
|
| Method: |
FISH |
| Comment: |
Testing is indicated when B-cell lymphoma patients experience transformation, relapse, or refractory disease. Samples received on holidays will be reported in the next schedule / next working day. |
| Report: |
Contact us to know the TAT. |
| Usage: |
This panel differentiates double-hit or triple-hit lymphomas (which have MYC rearrangements together with BCL2 and/or BCL6 rearrangements) from Burkitt lymphoma or diffuse large B-cell lymphoma. Double-hit and triple-hit lymphomas are difficult to classify morphologically without the aid of cytogenetics/FISH or IHC and are associated with an aggressive course. Clients may choose to add MYC/IgH/CEN8 t(8:14) and/or BCL2 break-apart testing to their initial test order. MYC/IgH/CEN8 will confirm heavy chain rearrangement when MYC is rearranged. BCL2 break-apart allows the inclusion of BCL2 rearrangements other than IgH/BCL2 t(14;18). Ideally, this panel should be ordered in all B-cell lymphomas with features intermediate between Diffuse large B-cell lymphoma (DLBCL) & Burkitt lymphoma (BL); any lymphoma with Ki-67 proliferation index >90%; any DLBCL which has recurred & is refractory to therapy. |
| Doctor Specialty: |
Hematologist, Oncologist |
| Disease: |
Lymphomas |
| Components: |
*BCL2 *BCL6 *c-MYC |
| Courier Charges: |
|
| Home Collection: |
Available (*T&C Apply) |
| Department: |
CYTOGENETICS |
| Pre Test Information: |
A duly filled Chromosome & FISH analysis Requisition Form is mandatory. |
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