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Laboratory

Exult Diagnostics, Dr. Lal PathLabs, Metropolis Labs, Oncquest Labs, Pathkind Labs

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VITAMIN B12, ACTIVE; HOLOTRANSCOBALAMIN

 1340 1750

EX2048      VITAMIN B12, ACTIVE; HOLOTRANSCOBALAMIN
Specimen: 2 mL (1 mL min.) serum from 1 SST. Ship refrigerated or frozen.
Stability:
Room Refrigerated Frozen
8 hrs 72 hrs 6 months
Method: CMIA
Comment:
Report: Contact us to know the TAT.
Usage: Vitamin B12 (Cobalamin) in serum is bound to two proteins: Transcobalamin (TC) and Haptocorrin (HC). The transcobalamin-vitamin B12 complex is called Holotranscobalamin (HoloTC). HoloTC contains the biologically available cobalamin as only HoloTC promotes the uptake of cobalamin by all cells via specific receptors. In comparison, approximately 80% of the cobalamin carried by HC is considered metabolically inert because no cellular receptors exist, with the exception of receptors found in the liver. The shorter circulating half-life of HoloTC compared to Holohaptocorrin (HoloHC) makes a decrease of HoloTC one of the earliest markers of cobalamin deficiency.
Doctor Specialty: Physician
Disease: Nutritional disorders
Components:
Courier Charges: 0.00
Home Collection: Available (*T&C Apply)
Department: Biochemistry
Pre Test Information: No special preparation required