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| Laboratory | Exult Diagnostics, Dr. Lal PathLabs |
|---|
₹ 4000
| EX1716 PIIINP (PROCOLLAGEN TYPE III AMINO TERMINAL PROPEPTIDE) | |||||||
| Specimen: | 3 mL (1.5 mL min.) serum from 1 SST. Ship refrigerated or frozen. Overnight fasting is preferred. | ||||||
| Stability: |
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| Method: | CLIA | ||||||
| Comment: | As per Expert Committee recommendations (Acta Derm Venereol 2017), the PIIINP test can be used to assess MTx-induced liver toxicity. Also, see ENHANCED LIVER FIBROSIS (ELF) PANEL. | ||||||
| Report: | Contact us to know the TAT. | ||||||
| Usage: | Procollagen type III amino-terminal propeptide (PIIINP) has been used in the assessment of liver fibrosis, as it is a marker of early fibrogenesis and inflammation. Methotrexate (MTX) is a widely used drug for the treatment of Psoriasis and other dermatological conditions. MTX has been recognized to be hepatotoxic which limits its therapeutic use. Thus, monitoring of the liver for structural and functional damage is recommended before and during treatment with MTX. PIIINP test can be used to assess MTx-induced liver toxicity, especially in high-risk individuals like patients with Metabolic Syndrome, Non-Alcoholic Fatty Liver Disease, excessive alcohol consumption, and Chronic Hepatitis B & C. This test has a sensitivity of 77% and specificity of 92% in the assessment of liver toxicity in MTx-treated patients with Psoriasis. | ||||||
| Doctor Specialty: | Dermatologist, Gastroenterologist | ||||||
| Disease: | Disorders of Skin & Liver | ||||||
| Components: | |||||||
| Courier Charges: | |||||||
| Home Collection: | Available (*T&C Apply) | ||||||
| Department: | Biochemistry | ||||||
| Pre Test Information: | Overnight fasting is preferred. | ||||||
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