| EX1493 METANEPHRINES FREE, PLASMA |
| Specimen: |
4 mL (2 mL min.) plasma from 2 Lavender top (EDTA) tubes. Overnight fasting is mandatory. Collect specimen with the patient in the supine position after a minimum of 30 minutes of rest. Immerse the specimen immediately in ice water. Separate plasma within 30 minutes and transfer into the sterile screw-capped vial. Ship refrigerated or frozen. |
| Stability: |
| Room |
Refrigerated |
Frozen |
| 6 hrs |
72 hrs |
3 months |
|
| Method: |
LC-MS / MS |
| Comment: |
Measurement of plasma-free metanephrines by LC-MS/MS is the test of the first choice in the diagnosis of Pheochromocytoma and Paraganglionomas because it has high diagnostic accuracy. Samples received on holidays will be reported in the next schedule/next working day. |
| Report: |
Contact us to know the TAT. |
| Usage: |
Metanephrines and Normetanephrines are elevated in catecholamine secreting tumors like Pheochromocytomas and in tumors derived from neural crest cells like Paraganglioma and Neuroblastoma. Measurement of plasma-free metanephrines appears to be the best test for excluding Pheochromocytoma as the test’s sensitivity is approximately 96-99 % and offers specificity between 80-100 %. Tumoral production of 3-methoxytyramine is associated with the presence of an underlying SDHB mutation and may be a biomarker of malignancy. Following patients with or without hypertension should be investigated for Pheochromocytoma: • Previous history of tumor • Adrenal incidentaloma • Hereditary predisposition |
| Doctor Specialty: |
Physician, Oncologist |
| Disease: |
Hypertension, Cancer |
| Components: |
*Metanephrine Free *Normetanephrine Free *3-Methoxytyramine |
| Courier Charges: |
|
| Home Collection: |
Available (*T&C Apply) |
| Department: |
GENETICS |
| Pre Test Information: |
Patients should strictly avoid drugs like Labetalol, Sotalol, Acetaminophen, Methyldopa, Antidepressants, and agents like Ephedrine, Amphetamine, Nicotine Caffeine, etc. Avoid foods like banana, pineapple, nuts, cereals, etc. at least 72 hours prior to sample collection. Overnight fasting is mandatory. |
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