| EX1480 MEMBRANOUS GLOMERULOPATHY (MGN) PLA2R Negative : TARGET 4 ANTIGEN PANEL |
| Specimen: |
Submit Kidney Biopsy tissue block / Kidney biopsy specimen in 10% formalin. Ship at room temperature. |
| Stability: |
| Room |
Refrigerated |
Frozen |
| NA |
NA |
NA |
|
| Method: |
Immunohistochemistry |
| Comment: |
|
| Report: |
Contact us to know the TAT. |
| Usage: |
Membranous nephropathy (MN) occurs due to the deposition of immune complexes along the subepithelial region of the glomerular basement membrane. Target antigens for the immune complexes remained elusive for a long until the discovery of, PLA2R (identified in 2009) and THSD7A (in 2014). These two antigens account for approximately 60% of all MN, both primary and secondary. The use of laser microdissection and mass spectrometry has enabled the identification of other new “antigens including exotosin 1 (EXT1) – and exotosin 2 (EXT2)–associated MN, NELL1-associated MN, Sema3B-associated MN, and more antigens continue to be discovered. Membranous nephropathy associated with each of these antigens represents a distinct disease entity, with different clinical and pathologic findings. |
| Doctor Specialty: |
Nephrologist |
| Disease: |
Disorders of Kidney |
| Components: |
*THSD7a *NELL 1 *Exostocin 1 *Semaphorin 3B |
| Courier Charges: |
|
| Home Collection: |
Available (*T&C Apply) |
| Department: |
Histopathology |
| Pre Test Information: |
Brief clinical history in Renal Biopsy-Native Kidneys Requisition Form is mandatory. |
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