| EX1411 LEUCOCYTE ADHESION DEFICIENCY (LAD I & II) |
| Specimen: |
3 mL (2 mL min.) whole blood in 1 Lavender Top (EDTA) tube AND 3 mL (2 mL min.) whole blood in 1 Green Top (Sodium Heparin) tube. Mix thoroughly & ship immediately at 18–22°C. DO NOT REFRIGERATE OR FREEZE. Specify the time of draw and date in the test request form. |
| Stability: |
| Room |
Refrigerated |
Frozen |
| 72 hrs |
NA |
NA |
|
| Method: |
Flow Cytometry |
| Comment: |
|
| Report: |
Contact us to know the TAT. |
| Usage: |
LAD is an autosomal recessive immunodeficiency disorder that affects the leucocyte adhesion process and is associated with recurrent bacterial and fungal infections. Two forms of LAD have been described. LAD-I is associated with defective expression of CD18 by neutrophils resulting from mutations in the integrin beta-2 gene (ITGB2), encoding CD18 of beta-2 integrins. LAD-II is associated with defective expression of CD15s (sialyl-Lewis X) resulting from mutations in the Glucose diphosphate (GDP)-fucose transporter gene. Genetic testing for the ITGB2 gene (associated with LAD-I) is recommended to verify specific mutations and confirm diagnosis while preparing for Hematopoietic Cell Transplantation (HCT). |
| Doctor Specialty: |
Pediatrician |
| Disease: |
Immunodeficiency Disorders |
| Components: |
*CD11a *CD11b *CD18 *CD15s |
| Courier Charges: |
|
| Home Collection: |
Available (*T&C Apply) |
| Department: |
FLOW CYTOMETRY |
| Pre Test Information: |
It is mandatory to provide clinical details & CBC report. |
Reviews
There are no reviews yet.