| EX1001 HLA HYPERSENSITIVITY TO CARBAMAZEPINE & PHENYTOIN (B*15:02) |
| Specimen: |
4 mL (3 mL min.) whole blood in 1 Lavender Top (EDTA) tube OR 6 mL (3 mL min.) whole blood in 1 Yellow Top (ACD) tube OR Buccal swab collected in a sterile container. Ship refrigerated. DO NOT FREEZE. |
| Stability: |
| Room |
Refrigerated |
Frozen |
| NA |
96 hrs |
NA |
|
| Method: |
PCR, Sequencing |
| Comment: |
|
| Report: |
Contact us to know the TAT. |
| Usage: |
Clinical studies have demonstrated an association between some HLA genotypes and drug-induced adverse skin reactions. The presence of the HLA B*15:02 allele increases the risk of developing Toxic Epidermal Necrolysis (TEN) or Stevens-Johnson Syndrome (SJS) which is a milder form of TEN. The frequency of this allele is 10-15% in Chinese, 2-4% in southeast Asians including Indians, and <1% in Japanese & Koreans. This allele has also been associated with adverse reactions to Lamotrigine used for treating Epilepsy and Bipolar disorder. |
| Doctor Specialty: |
Neurologist, Dermatologist |
| Disease: |
Disorders of Nervous System, Disorders of Skin |
| Components: |
|
| Courier Charges: |
0.00 |
| Home Collection: |
Available (*T&C Apply) |
| Department: |
Molecular Diagnostics |
| Pre Test Information: |
No special preparation required |
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