| EX1000 HLA HYPERSENSITIVITY TO ALLOPURINOL (B*58:01) |
| Specimen: |
4 mL (3 mL min.) whole blood in 1 Lavender Top (EDTA) tube OR 6 mL (3 mL min.) whole blood in 1 Yellow Top (ACD) tube OR Buccal swab collected in a sterile container. Ship refrigerated. DO NOT FREEZE. |
| Stability: |
| Room |
Refrigerated |
Frozen |
| NA |
96 hrs |
NA |
|
| Method: |
PCR, Sequencing |
| Comment: |
|
| Report: |
Contact us to know the TAT. |
| Usage: |
The presence of HLA B*58:01 is associated with hypersensitivity to Allopurinol therapy. Allopurinol is widely used for hyperuricemia-related diseases such as Gout, Lesch- Nyhan Syndrome, and recurrent urate kidney stones. Such individuals are at risk of developing Allopurinol hypersensitivity syndrome which includes Toxic Epidermal Necrolysis (TEN) or Stevens-Johnson Syndrome (SJS) and also features of eosinophilia, vasculitis, and major end-organ disease. Patients of Han Chinese or Thai descent are at very high risk of developing Allopurinol hypersensitivity syndrome. Therapy should be discontinued immediately and permanently if Allopurinol hypersensitivity syndrome develops. |
| Doctor Specialty: |
Nephrologist |
| Disease: |
Disorders of Kidney |
| Components: |
|
| Courier Charges: |
0.00 |
| Home Collection: |
Available (*T&C Apply) |
| Department: |
Molecular Diagnostics |
| Pre Test Information: |
No special preparation required |
Reviews
There are no reviews yet.