| EX0692 FISH: NTRK1 GENE REARRANGEMENT ASSAY |
| Specimen: |
Submit formalin-fixed paraffin-embedded Tissue Block. Ship at room temperature. Tissue block must contain at least 10% tumor tissue. |
| Stability: |
| Room |
Refrigerated |
Frozen |
| NA |
NA |
NA |
|
| Method: |
FISH |
| Comment: |
Samples received on holidays will be reported in the next schedule / next working day. |
| Report: |
Contact us to know the TAT. |
| Usage: |
NTRK1 gene is located on chromosome 1q21-q22,4 and rearrangements have been shown to be involved in thyroid carcinogenesis. Several studies show that NTRK1 rearrangements may be associated with a worse clinical course when compared with NTRK1 rearrangement-negative Papillary Thyroid Carcinomas. The treatment of patients with NTRK fusion-positive cancers with an NTRK inhibitor, such as the FDA-approved drugs Larotrectinib or Entrectinib, is associated with high response rates regardless of the NTRK gene, fusion partner, and tumor type. Hence, detection of NTRK1 rearrangements by in situ Hybridization may be of prognostic and therapeutic significance. |
| Doctor Specialty: |
Oncologist |
| Disease: |
Cancer |
| Components: |
*NTRK1 (1q21.3) |
| Courier Charges: |
|
| Home Collection: |
Available (*T&C Apply) |
| Department: |
CYTOGENETICS |
| Pre Test Information: |
A duly filled Chromosome & FISH analysis Requisition Form is mandatory. |
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