| EX0688 FISH: MULTIPLE MYELOMA WITH POSITIVE SELECTION OF CD138 CELLS |
| Specimen: |
5 mL (3 mL min.) Whole blood OR 4 mL (2 mL min.) Bone Marrow from 2 Green Top (Sodium Heparin) tubes. Ship at 18-22°C. DO NOT FREEZE. Bone marrow is the preferred sample. |
| Stability: |
| Room |
Refrigerated |
Frozen |
| 48 hrs |
NA |
NA |
|
| Method: |
FISH |
| Comment: |
Bone marrow is the preferred sample. FISH is performed after a positive selection of CD138 cells thereby providing more accurate results. Samples received on holidays will be reported in the next schedule / next working day. |
| Report: |
Contact us to know the TAT. |
| Usage: |
Conventional Cytogenetics detects abnormal karyotype in 40% newly diagnosed Myeloma cases. Based on conventional karyotyping there are two prognostic groups: Hyperdiploid (48-75 chromosomes ) associated with favourable prognosis and Non-hyperdiploid (<48 & >75 chromosomes) associated with an unfavourable prognosis. Abnormalities detected by FISH after positive selection of CD138 cells, has predictive usefulness namely- High risk disease: if t(14:16), t(14;20), del17p & del1p detected; Standard risk disease: if t(11:14), t(6;14) &/or trisomies detected; Intermediate risk: if t(4;14) & gain(1q21) detected. |
| Doctor Specialty: |
Oncologist |
| Disease: |
Multiple Myeloma |
| Components: |
*del 13q14.3 *del 17p13.1 *t(11;14) CCND1/IGH *t(4;14) FGFR3/IGH *t(14;16) IGH/MAF *Gain 1q |
| Courier Charges: |
0.00 |
| Home Collection: |
Available (*T&C Apply) |
| Department: |
CYTOGENETICS |
| Pre Test Information: |
A duly filled Chromosome & FISH analysis Requisition Form is mandatory. |
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