| EX0676 FISH: FGFR1 (8p12) GENE REARRANGEMENT |
| Specimen: |
5 mL (3 mL min.) Whole blood OR 4 mL (2 mL min.) Bone Marrow from 2 Green Top (Sodium Heparin) tubes. Ship at 18-22°C. DO NOT FREEZE. |
| Stability: |
| Room |
Refrigerated |
Frozen |
| 48 hrs |
NA |
NA |
|
| Method: |
FISH |
| Comment: |
Samples received on holidays will be reported in the next schedule / next working day. |
| Report: |
Contact us to know the TAT. |
| Usage: |
Myeloid & lymphoid hematological malignancies with eosinophilia and abnormalities of Fibroblast growth factor receptor-1 (FGFR1) result from the formation of abnormal fusion genes that encode constitutively activated tyrosine kinases. Rearrangement of FGFR1 gene locus leads to more than 10 fused genes, which code for fusion proteins containing N-terminal derived from a partner gene and C-terminal of tyrosine kinase domain from the FGFR1 gene, which causes constitutive activation of FGFR1. Patients with FGFR1 rearrangement usually initiate with Myeloproliferative neoplasm (MPN) and undergo diverse clinical courses such as Lymphoblastic lymphoma (LBL), and Acute lymphoblastic leukemia (ALL), or Acute myeloid leukemia (AML). |
| Doctor Specialty: |
Oncologist, Hematologist |
| Disease: |
Leukemia |
| Components: |
|
| Courier Charges: |
0.00 |
| Home Collection: |
Available (*T&C Apply) |
| Department: |
CYTOGENETICS |
| Pre Test Information: |
A duly filled Chromosome & FISH analysis Requisition Form is mandatory. |
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