| EX0671 FISH: c-MYC AMPLIFICATION |
| Specimen: |
Submit formalin-fixed paraffin-embedded Tissue Block. Ship at room temperature. Tissue block must contain at least 10% tumor tissue OR 4 mL (3 mL min.) Whole blood OR 4 mL (2 mL min.) Bone Marrow from 1 Green Top (Sodium Heparin) tube. Ship at 18-22°C. DO NOT FREEZE. |
| Stability: |
| Room |
Refrigerated |
Frozen |
| 48 hrs |
NA |
NA |
|
| Method: |
FISH |
| Comment: |
Samples received on holidays will be reported in the next schedule / next working day. |
| Report: |
Contact us to know the TAT. |
| Usage: |
Dysregulation of c-MYC is essential in the pathogenesis of B-cell lymphomas but is rarely reported in T-cell lymphomas. c-MYC gene translocation on chromosome 8 is a hallmark of Burkitt lymphoma. However, the correlation between c-MYC, BCL2 & BCL6 protein expression & gene translocation act as biomarkers in the diagnosis & prognosis of Diffuse large B-cell lymphoma (DLBCL). c-MYC amplification may be seen in myeloid or lymphoid neoplasms and indicates advanced, drug-resistant disease. |
| Doctor Specialty: |
Oncologist |
| Disease: |
Lymphoma |
| Components: |
|
| Courier Charges: |
0.00 |
| Home Collection: |
Available (*T&C Apply) |
| Department: |
CYTOGENETICS |
| Pre Test Information: |
A duly filled Chromosome & FISH analysis Requisition Form is mandatory. |
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