| EX0669 FISH: BCR / ABL OR PHILADELPHIA TRANSLOCATION |
| Specimen: |
5 mL (3 mL min.) Whole blood OR 4 mL ( 2 mL min.) Bone Marrow from 2 Green Top (Sodium Heparin) tubes. Ship at 18-22°C. DO NOT FREEZE. |
| Stability: |
| Room |
Refrigerated |
Frozen |
| 48 hrs |
NA |
NA |
|
| Method: |
FISH |
| Comment: |
Samples received on holidays will be reported in the next schedule / next working day. |
| Report: |
Contact us to know the TAT. |
| Usage: |
The t(9;22) is a balanced translocation between chromosomes 9 & 22 leading to the fusion of bcr & c-abl genes and to the transcription of leukemia-specific bcr-abl mRNAs. Philadelphia (Ph) chromosome causing the BCR/ABL fusion, is present in approximately 95% of cases of chronic myeloid leukemia (CML) and 25-30% cases of Acute lymphoblastic leukemia (ALL). Due to the development of potent tyrosine kinase inhibitors & anti-sense therapies, the presence of BCR/ABL translocation is a favorable prognostic marker. |
| Doctor Specialty: |
Oncologist, Hematologist |
| Disease: |
Leukemia |
| Components: |
|
| Courier Charges: |
0.00 |
| Home Collection: |
Available (*T&C Apply) |
| Department: |
CYTOGENETICS |
| Pre Test Information: |
A duly filled Chromosome & FISH analysis Requisition Form is mandatory. |
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