| EX0663 FISH: ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) EXTENDED PANEL, HYPODIPLOIDY / HYPERDIPLOIDY |
| Specimen: |
8 ml (6 ml min.) Whole blood from 2 Green Top (Sodium Heparin) tubes AND 4 ml ( 2 ml min.). Bone marrow from Green Top (Sodium Heparin) tube. Ship at 18-22°C. DO NOT FREEZE. |
| Stability: |
| Room |
Refrigerated |
Frozen |
| Ship at a specified temperature |
Ship at a specified temperature |
Ship at a specified temperature |
|
| Method: |
FISH |
| Comment: |
Samples received on holidays will be reported in the next schedule / next working day. |
| Report: |
Contact us to know the TAT. |
| Usage: |
ALL is a malignant clonal proliferation of lymphoid progenitor cells, most commonly of the B-cell lineage (B-ALL). In the pediatric population, ALL accounts for 81% of childhood leukemias. In general, hypodiploidy with less than 40 chromosomes confers a poor prognosis. Twenty to twenty-five percent of ALL display high hyperdiploidy (51-67 chromosomes), making high hyperdiploid cases one of the largest subgroups of pediatric cancer. Conventional chromosome analysis and FISH can detect the majority of these anomalies and aid in tracking response to therapy. |
| Doctor Specialty: |
Hematologist, Oncologist |
| Disease: |
Cancer |
| Components: |
*ETV6/RUNX1 (aka TEL/AML1) dual-fusion probe to detect t(12;21) & variants; this translocation is cryptic by chromosome analysis *BCR/ABL + ASS dual-fusion probe to detect t(9;22) and variants *MLL breakapart probe to detect MLL (11q23.1-11q23.3) rearrangement *CEP 4/ CEP 6/CEP 10/ CEP 17/CEP 21/ CEP X enumeration probes to detect hyperdiploidy involving trisomies of chromosomes 4, 6, 10, 17 and X *E2A/PBX1 dual-fusion probe to detect t(1;19) & variants *CDKN2A (p16) / CEP 9 to detect loss of 9p21 region |
| Courier Charges: |
|
| Home Collection: |
Available (*T&C Apply) |
| Department: |
CYTOGENETICS |
| Pre Test Information: |
A duly filled chromosome and FISH analysis Requisition form is mandatory. |
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